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The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

The enterococcal cytolysin is a virulence factor consisting of two post-translationally modified peptides that synergistically kill human immune cells. Both peptides are made by CylM, a member of the LanM lanthipeptide synthetases. CylM catalyzes seven dehydrations of Ser and Thr residues and three...

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Detalles Bibliográficos
Autores principales: Dong, Shi-Hui, Tang, Weixin, Lukk, Tiit, Yu, Yi, Nair, Satish K, van der Donk, Wilfred A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550811/
https://www.ncbi.nlm.nih.gov/pubmed/26226635
http://dx.doi.org/10.7554/eLife.07607