Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii

Streptomyces leeuwenhoekii, isolated from the hyperarid Atacama Desert, produces the new ansamycin-like compounds chaxamycins A to D, which possess potent antibacterial activity and moderate antiproliferative activity. We report the development of genetic tools to manipulate S. leeuwenhoekii and the...

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Detalles Bibliográficos
Autores principales: Castro, Jean Franco, Razmilic, Valeria, Gomez-Escribano, Juan Pablo, Andrews, Barbara, Asenjo, Juan A., Bibb, Mervyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551226/
https://www.ncbi.nlm.nih.gov/pubmed/26092459
http://dx.doi.org/10.1128/AEM.01039-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551226/
https://www.ncbi.nlm.nih.gov/pubmed/26092459
http://dx.doi.org/10.1128/AEM.01039-15

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