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Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii

Streptomyces leeuwenhoekii, isolated from the hyperarid Atacama Desert, produces the new ansamycin-like compounds chaxamycins A to D, which possess potent antibacterial activity and moderate antiproliferative activity. We report the development of genetic tools to manipulate S. leeuwenhoekii and the...

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Detalles Bibliográficos
Autores principales:	Castro, Jean Franco, Razmilic, Valeria, Gomez-Escribano, Juan Pablo, Andrews, Barbara, Asenjo, Juan A., Bibb, Mervyn J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2015
Materias:	Genetics and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551226/ https://www.ncbi.nlm.nih.gov/pubmed/26092459 http://dx.doi.org/10.1128/AEM.01039-15

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