Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment

Type II endometrial carcinomas are estrogen independent, poorly differentiated tumors that behave in an aggressive manner. Since TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phen...

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Detalles Bibliográficos
Autores principales: Stodden, Genna R., Lindberg, Mallory E., King, Mandy L., Paquet, Marilène, MacLean, James A., Mann, Jordan L., DeMayo, Francesco J., Lydon, John P., Hayashi, Kanako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551401/
https://www.ncbi.nlm.nih.gov/pubmed/24998851
http://dx.doi.org/10.1038/onc.2014.193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551401/
https://www.ncbi.nlm.nih.gov/pubmed/24998851
http://dx.doi.org/10.1038/onc.2014.193

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