Translational biomarkers of acetaminophen-induced acute liver injury

Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial in...

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Autores principales: Beger, Richard D., Bhattacharyya, Sudeepa, Yang, Xi, Gill, Pritmohinder S., Schnackenberg, Laura K., Sun, Jinchun, James, Laura P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551536/
https://www.ncbi.nlm.nih.gov/pubmed/25983262
http://dx.doi.org/10.1007/s00204-015-1519-4
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author Beger, Richard D.
Bhattacharyya, Sudeepa
Yang, Xi
Gill, Pritmohinder S.
Schnackenberg, Laura K.
Sun, Jinchun
James, Laura P.
author_facet Beger, Richard D.
Bhattacharyya, Sudeepa
Yang, Xi
Gill, Pritmohinder S.
Schnackenberg, Laura K.
Sun, Jinchun
James, Laura P.
author_sort Beger, Richard D.
collection PubMed
description Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.
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spelling pubmed-45515362015-09-01 Translational biomarkers of acetaminophen-induced acute liver injury Beger, Richard D. Bhattacharyya, Sudeepa Yang, Xi Gill, Pritmohinder S. Schnackenberg, Laura K. Sun, Jinchun James, Laura P. Arch Toxicol Review Article Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury. Springer Berlin Heidelberg 2015-05-17 2015 /pmc/articles/PMC4551536/ /pubmed/25983262 http://dx.doi.org/10.1007/s00204-015-1519-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Beger, Richard D.
Bhattacharyya, Sudeepa
Yang, Xi
Gill, Pritmohinder S.
Schnackenberg, Laura K.
Sun, Jinchun
James, Laura P.
Translational biomarkers of acetaminophen-induced acute liver injury
title Translational biomarkers of acetaminophen-induced acute liver injury
title_full Translational biomarkers of acetaminophen-induced acute liver injury
title_fullStr Translational biomarkers of acetaminophen-induced acute liver injury
title_full_unstemmed Translational biomarkers of acetaminophen-induced acute liver injury
title_short Translational biomarkers of acetaminophen-induced acute liver injury
title_sort translational biomarkers of acetaminophen-induced acute liver injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551536/
https://www.ncbi.nlm.nih.gov/pubmed/25983262
http://dx.doi.org/10.1007/s00204-015-1519-4
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