Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)

Many regulatory agencies are exploring ways to integrate toxicogenomic data into their chemical risk assessments. The major challenge lies in determining how to distill the complex data produced by high-content, multi-dose gene expression studies into quantitative information. It has been proposed t...

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Detalles Bibliográficos
Autores principales: Webster, A. Francina, Chepelev, Nikolai, Gagné, Rémi, Kuo, Byron, Recio, Leslie, Williams, Andrew, Yauk, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551741/
https://www.ncbi.nlm.nih.gov/pubmed/26313361
http://dx.doi.org/10.1371/journal.pone.0136764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551741/
https://www.ncbi.nlm.nih.gov/pubmed/26313361
http://dx.doi.org/10.1371/journal.pone.0136764

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