Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation

TAR DNA binding protein 43 (TDP-43) A315T mutation (TDP-43(A315T)) has been found in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) as a disease causing mutation with enhanced protein aggregation, formation of protease-resistant fragments, and neurotoxicity. However...

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Detalles Bibliográficos
Autores principales: Wang, Xuejing, Zhou, Shuang, Ding, Xuebing, Ma, Mingming, Zhang, Jiewen, Zhou, Yue, Wu, Erxi, Teng, Junfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551750/
https://www.ncbi.nlm.nih.gov/pubmed/26327808
http://dx.doi.org/10.7150/ijbs.12657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551750/
https://www.ncbi.nlm.nih.gov/pubmed/26327808
http://dx.doi.org/10.7150/ijbs.12657

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