A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation

Mammalian nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that degrades mRNAs containing premature translation termination codons. Phosphorylation of the essential NMD effector UPF1 by the phosphoinositide-3-kinase-like kinase (PIKK) SMG-1 is a key step in NMD and occurs wh...

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Detalles Bibliográficos
Autores principales: Deniaud, Aurélien, Karuppasamy, Manikandan, Bock, Thomas, Masiulis, Simonas, Huard, Karine, Garzoni, Frédéric, Kerschgens, Kathrin, Hentze, Matthias W., Kulozik, Andreas E., Beck, Martin, Neu-Yilik, Gabriele, Schaffitzel, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551919/
https://www.ncbi.nlm.nih.gov/pubmed/26130714
http://dx.doi.org/10.1093/nar/gkv668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551919/
https://www.ncbi.nlm.nih.gov/pubmed/26130714
http://dx.doi.org/10.1093/nar/gkv668

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