Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1

MicroRNA-122 (miR-122), which is expressed at high levels in hepatocytes, is selectively stabilized by 3′-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Here, we report that poly(A)-specific ribonuclease (PARN) is responsible for the deadenylation and destabilization of miR-122. T...

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Detalles Bibliográficos
Autores principales: Katoh, Takayuki, Hojo, Hiroaki, Suzuki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551920/
https://www.ncbi.nlm.nih.gov/pubmed/26130707
http://dx.doi.org/10.1093/nar/gkv669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551920/
https://www.ncbi.nlm.nih.gov/pubmed/26130707
http://dx.doi.org/10.1093/nar/gkv669

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