Generation of supercoils in nicked and gapped DNA drives DNA unknotting and postreplicative decatenation

Due to the helical structure of DNA the process of DNA replication is topologically complex. Freshly replicated DNA molecules are catenated with each other and are frequently knotted. For proper functioning of DNA it is necessary to remove all of these entanglements. This is done by DNA topoisomeras...

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Detalles Bibliográficos
Autores principales: Racko, Dusan, Benedetti, Fabrizio, Dorier, Julien, Burnier, Yannis, Stasiak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551925/
https://www.ncbi.nlm.nih.gov/pubmed/26150424
http://dx.doi.org/10.1093/nar/gkv683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551925/
https://www.ncbi.nlm.nih.gov/pubmed/26150424
http://dx.doi.org/10.1093/nar/gkv683

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