Adenine versus guanine DNA adducts of aristolochic acids: role of the carcinogen–purine linkage in the differential global genomic repair propensity

Computational modeling is employed to provide a plausible structural explanation for the experimentally-observed differential global genome repair (GGR) propensity of the ALII-N(2)-dG and ALII-N(6)-dA DNA adducts of aristolochic acid II. Our modeling studies suggest that an intrinsic twist at the ca...

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Detalles Bibliográficos
Autores principales: Kathuria, Preetleen, Sharma, Purshotam, Wetmore, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551933/
https://www.ncbi.nlm.nih.gov/pubmed/26175048
http://dx.doi.org/10.1093/nar/gkv701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551933/
https://www.ncbi.nlm.nih.gov/pubmed/26175048
http://dx.doi.org/10.1093/nar/gkv701

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