Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

Autophagy is a cellular catabolic process critical for cell viability and homoeostasis. Inhibition of mammalian target of rapamycin (mTOR) complex-1 (mTORC1) activates autophagy. A puzzling observation is that amino acid starvation triggers more rapid autophagy than pharmacological inhibition of mTO...

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Detalles Bibliográficos
Autores principales: Wong, Pui-Mun, Feng, Yan, Wang, Junru, Shi, Rong, Jiang, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552084/
https://www.ncbi.nlm.nih.gov/pubmed/26310906
http://dx.doi.org/10.1038/ncomms9048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552084/
https://www.ncbi.nlm.nih.gov/pubmed/26310906
http://dx.doi.org/10.1038/ncomms9048

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