A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation. One such modified BCG vaccine candidate has been withdrawn from human clinical trials due to adverse effects. BCG was derived fr...

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Detalles Bibliográficos
Autores principales: Shoen, Carolyn M., DeStefano, Michelle S., Hager, Cynthia C., Tham, Kyi-Toe, Braunstein, Miriam, Allen, Alexandria D., Gates, Hiriam O., Cynamon, Michael H., Kernodle, Douglas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552197/
https://www.ncbi.nlm.nih.gov/pubmed/26343849
http://dx.doi.org/10.3390/vaccines1010034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552197/
https://www.ncbi.nlm.nih.gov/pubmed/26343849
http://dx.doi.org/10.3390/vaccines1010034

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