Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

Gaucher’s disease is caused by defects in acid β-glucosidase 1 (GBA1) and has been also proposed as an inflammatory disease. GBA1 cleaves glucosylceramide to form ceramide, an established bioactive lipid, and defects in GBA1 lead to aberrant accumulation in glucosylceramide and insufficient formatio...

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Detalles Bibliográficos
Autores principales: Kitatani, Kazuyuki, Wada, Masayuki, Perry, David, Usui, Toshinori, Sun, Ying, Obeid, Lina M., Yaegashi, Nobuo, Grabowski, Gregory A., Hannun, Yusuf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552301/
https://www.ncbi.nlm.nih.gov/pubmed/26312487
http://dx.doi.org/10.1371/journal.pone.0136633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552301/
https://www.ncbi.nlm.nih.gov/pubmed/26312487
http://dx.doi.org/10.1371/journal.pone.0136633

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