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Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33

BACKGROUND: Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little is known regarding factors involved in BSMC production of IL-33. Rhinovirus (RV) infections cause asthma exacerbations, which...

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Detalles Bibliográficos
Autores principales: Calvén, Jenny, Akbarshahi, Hamid, Menzel, Mandy, Ayata, Cemil Korcan, Idzko, Marco, Bjermer, Leif, Uller, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552418/
https://www.ncbi.nlm.nih.gov/pubmed/26318341
http://dx.doi.org/10.1186/s12967-015-0645-3