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Removal of H2A.Z by INO80 promotes homologous recombination

The mammalian INO80 remodelling complex facilitates homologous recombination (HR), but the mechanism by which it does this is unclear. Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with H2A/H2B dimers. H2A.Z is actively incorporated at sites of damage in mammalian c...

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Detalles Bibliográficos
Autores principales: Alatwi, Hanan E, Downs, Jessica A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552491/
https://www.ncbi.nlm.nih.gov/pubmed/26142279
http://dx.doi.org/10.15252/embr.201540330