High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy

Autophagy, macroautophagy and chaperone-mediated autophagy (CMA), are upregulated in pressure overload (PO) hypertrophy. In this study, we targeted this process at its induction using 3 methyladenine and at the lysosomal level using chloroquine and evaluated the effects of these modulations on cardi...

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Detalles Bibliográficos
Autores principales: Chaanine, Antoine H, Gordon, Ronald E, Nonnenmacher, Mathieu, Kohlbrenner, Erik, Benard, Ludovic, Hajjar, Roger J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552516/
https://www.ncbi.nlm.nih.gov/pubmed/26152691
http://dx.doi.org/10.14814/phy2.12413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552516/
https://www.ncbi.nlm.nih.gov/pubmed/26152691
http://dx.doi.org/10.14814/phy2.12413

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