Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice

Skeletal muscle mitochondrial degeneration is a hallmark of insulin resistance/obesity marked by lost function, enhanced ROS emission, and altered morphology which may be ameliorated by physical activity (PA). However, no prior report has examined mitochondrial quality control regulation throughout...

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Detalles Bibliográficos
Autores principales: Greene, Nicholas P, Lee, David E, Brown, Jacob L, Rosa, Megan E, Brown, Lemuel A, Perry, Richard A, Henry, Jordyn N, Washington, Tyrone A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552545/
https://www.ncbi.nlm.nih.gov/pubmed/26177961
http://dx.doi.org/10.14814/phy2.12470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552545/
https://www.ncbi.nlm.nih.gov/pubmed/26177961
http://dx.doi.org/10.14814/phy2.12470

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