Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice

Skeletal muscle mitochondrial degeneration is a hallmark of insulin resistance/obesity marked by lost function, enhanced ROS emission, and altered morphology which may be ameliorated by physical activity (PA). However, no prior report has examined mitochondrial quality control regulation throughout...

Descripción completa

Detalles Bibliográficos
Autores principales: Greene, Nicholas P, Lee, David E, Brown, Jacob L, Rosa, Megan E, Brown, Lemuel A, Perry, Richard A, Henry, Jordyn N, Washington, Tyrone A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552545/
https://www.ncbi.nlm.nih.gov/pubmed/26177961
http://dx.doi.org/10.14814/phy2.12470

Ejemplares similares

Ejemplares similares