Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis

Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10–20% long-term survival. The factors and pathways regulating these processes remain unclear, yet their identification is crucial in order to find new therapeutic targets. In this study we used a multi-omic...

Descripción completa

Detalles Bibliográficos
Autores principales: Endo-Munoz, Liliana, Cai, Na, Cumming, Andrew, Macklin, Rebecca, Merida de Long, Lilia, Topkas, Eleni, Mukhopadhyay, Pamela, Hill, Michelle, Saunders, Nicholas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552671/
https://www.ncbi.nlm.nih.gov/pubmed/26317203
http://dx.doi.org/10.1371/journal.pone.0133592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552671/
https://www.ncbi.nlm.nih.gov/pubmed/26317203
http://dx.doi.org/10.1371/journal.pone.0133592

Ejemplares similares