Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening

Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons of the substantia nigra. The hallmark of PD is the appearance of neuronal protein aggregations known as Lewy bodies and Lewy neurites, of which α-synuclein forms a major component. Familial PD...

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Detalles Bibliográficos
Autores principales: Dansithong, Warunee, Paul, Sharan, Scoles, Daniel R., Pulst, Stefan M., Huynh, Duong P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552753/
https://www.ncbi.nlm.nih.gov/pubmed/26317803
http://dx.doi.org/10.1371/journal.pone.0136930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552753/
https://www.ncbi.nlm.nih.gov/pubmed/26317803
http://dx.doi.org/10.1371/journal.pone.0136930

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