Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates

Intracellular protein aggregation is the hallmark of several neurodegenerative diseases. Aggregates formed by polyglutamine (polyQ)-expanded proteins, such as Huntingtin, adopt amyloid-like structures that are resistant to denaturation. We used a novel purification strategy to isolate aggregates for...

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Detalles Bibliográficos
Autores principales: Wear, Maggie P., Kryndushkin, Dmitry, O’Meally, Robert, Sonnenberg, Jason L., Cole, Robert N., Shewmaker, Frank P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552826/
https://www.ncbi.nlm.nih.gov/pubmed/26317359
http://dx.doi.org/10.1371/journal.pone.0136362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552826/
https://www.ncbi.nlm.nih.gov/pubmed/26317359
http://dx.doi.org/10.1371/journal.pone.0136362

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