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Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates
Intracellular protein aggregation is the hallmark of several neurodegenerative diseases. Aggregates formed by polyglutamine (polyQ)-expanded proteins, such as Huntingtin, adopt amyloid-like structures that are resistant to denaturation. We used a novel purification strategy to isolate aggregates for...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552826/ https://www.ncbi.nlm.nih.gov/pubmed/26317359 http://dx.doi.org/10.1371/journal.pone.0136362 |