Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease

The activity of beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is elevated during aging and in sporadic Alzheimer’s disease (AD), but the underlying mechanisms of this change are not well understood. p25/Cyclin-dependent kinase 5 (Cdk5) has been implicated in the pathogenesis of...

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Detalles Bibliográficos
Autores principales: Song, Woo-Joo, Son, Mi-Young, Lee, Hye-Won, Seo, Hyemyung, Kim, Jeong Hee, Chung, Sul-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552876/
https://www.ncbi.nlm.nih.gov/pubmed/26317805
http://dx.doi.org/10.1371/journal.pone.0136950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552876/
https://www.ncbi.nlm.nih.gov/pubmed/26317805
http://dx.doi.org/10.1371/journal.pone.0136950

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