Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice

The Rb and Pten tumor suppressor genes are important regulators of bone development and both are frequently mutated in the bone cancer osteosarcoma (OS). To determine if Rb1 and Pten synergize as tumor suppressor genes for osteosarcoma, we co-deleted them in osteoprogenitor cells. Surprisingly, we o...

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Detalles Bibliográficos
Autores principales: Filtz, Emma A., Emery, Ann, Lu, Huarui, Forster, Colleen L., Karasch, Chris, Hallstrom, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552947/
https://www.ncbi.nlm.nih.gov/pubmed/26317218
http://dx.doi.org/10.1371/journal.pone.0136729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552947/
https://www.ncbi.nlm.nih.gov/pubmed/26317218
http://dx.doi.org/10.1371/journal.pone.0136729

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