Cargando…

Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice

The Rb and Pten tumor suppressor genes are important regulators of bone development and both are frequently mutated in the bone cancer osteosarcoma (OS). To determine if Rb1 and Pten synergize as tumor suppressor genes for osteosarcoma, we co-deleted them in osteoprogenitor cells. Surprisingly, we o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Filtz, Emma A., Emery, Ann, Lu, Huarui, Forster, Colleen L., Karasch, Chris, Hallstrom, Timothy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552947/ https://www.ncbi.nlm.nih.gov/pubmed/26317218 http://dx.doi.org/10.1371/journal.pone.0136729

Ejemplares similares

Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas
por: Xie, Chencheng, et al.
Publicado: (2015)

The Rapidly Expanding Group of RB1-Deleted Soft Tissue Tumors: An Updated Review
por: Libbrecht, Sasha, et al.
Publicado: (2021)

Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235
por: Xie, Chencheng, et al.
Publicado: (2017)

Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice
por: Xu, Eugenia Y., et al.
Publicado: (2020)

Rb suppresses human cone precursor-derived retinoblastoma tumors
por: Xu, Xiaoliang L., et al.
Publicado: (2014)

The Effects of Various Mouthwashes on Osteoblast Precursor Cells
por: Song, In-Seok, et al.
Publicado: (2019)

Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice
por: Vallabhaneni, Sreeram, et al.
Publicado: (2021)

Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L
por: Lu, Huarui, et al.
Publicado: (2012)

Deletion of Gb3 Synthase in Mice Resulted in the Attenuation of Bone Formation via Decrease in Osteoblasts
por: Hamamura, Kazunori, et al.
Publicado: (2019)

Insights into the osteoblast precursor differentiation towards mature osteoblasts induced by continuous BMP-2 signaling
por: Zouani, Omar F., et al.
Publicado: (2013)

In vivo administration of histoincompatible lymphocytes leads to rapid functional deletion of cytotoxic T lymphocyte precursors
Publicado: (1989)

Infantile macrocephaly and multiple subcutaneous lipomas diagnosed with PTEN hamartoma tumor syndrome: A case report
por: Yotsumoto, Yuka, et al.
Publicado: (2020)

Broccoli, PTEN deletion and prostate cancer: where is the link?
por: Appendino, Giovanni, et al.
Publicado: (2010)

Artificial Extracellular Matrices with Oversulfated Glycosaminoglycan Derivatives Promote the Differentiation of Osteoblast-Precursor Cells and Premature Osteoblasts
por: Hempel, Ute, et al.
Publicado: (2014)

Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone
por: Paiva, Ana E., et al.
Publicado: (2017)

To Rb or not to Rb
por: Wells, William A.
Publicado: (2002)

Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68
por: Yaung, Stephanie J., et al.
Publicado: (2015)

Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation
por: Shu, Bing, et al.
Publicado: (2020)

The effect Akt2 deletion on tumor development in Pten(+/−) mice
por: Xu, P-Z, et al.
Publicado: (2012)

PTEN Deletion Enhances the Regenerative Ability of Adult Corticospinal Neurons
por: Liu, Kai, et al.
Publicado: (2010)

Partial PTEN deletion is linked to poor prognosis in breast cancer
por: Lebok, P., et al.
Publicado: (2015)

Mice Lacking Pten in Osteoblasts Have Improved Intramembranous and Late Endochondral Fracture Healing
por: Burgers, Travis A., et al.
Publicado: (2013)

Effect of Osteoblast‐Specific Deletion of the Proton Receptor OGR1
por: Krieger, Nancy S, et al.
Publicado: (2022)

Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity
por: Lu, Huarui, et al.
Publicado: (2016)

Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma
por: Wang, Xiaoxiao, et al.
Publicado: (2018)

Pericallosal lipoma associated with subcutaneous lipoma in an adult
por: Karabağ, Hamza, et al.
Publicado: (2014)

NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts
por: Ye, Ling, et al.
Publicado: (2018)

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
por: Sun, Fang, et al.
Publicado: (2011)

An intronic polymorphic deletion in the PTEN gene: implications for molecular diagnostic testing
por: Sandell, S, et al.
Publicado: (2013)

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors
por: Smith, Amanda M., et al.
Publicado: (2019)

Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors
por: Engel, B E, et al.
Publicado: (2013)

RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo
por: Bourgo, Ryan J., et al.
Publicado: (2011)

Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation
por: Freytsis, Marina, et al.
Publicado: (2018)

The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells
por: Kirstein, Anna S., et al.
Publicado: (2019)

Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice
por: Nara, Yasuhiko, et al.
Publicado: (2020)

Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts
por: McCarthy, Emma M., et al.
Publicado: (2018)

Cell Condensation Triggers the Differentiation of Osteoblast Precursor Cells to Osteocyte-Like Cells
por: Kim, Jeonghyun, et al.
Publicado: (2019)

YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulated bone development
por: Collins, Joseph M., et al.
Publicado: (2023)

Whistling Lipoma: Bronchial Obstruction Caused by a Lipoma
por: Azhar, Waqas, et al.
Publicado: (2020)

Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors
por: Carson, Robert P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rog39v8lk7e82rs3f079aqe7e6