The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

Cytokinesis requires activation of the GTPase RhoA. ECT-2, the exchange factor responsible for RhoA activation, is regulated to ensure spatiotemporal control of contractile ring assembly. Centralspindlin, composed of the Rho family GTPase-activating protein (RhoGAP) MgcRacGAP/CYK-4 and the kinesin M...

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Detalles Bibliográficos
Autores principales: Zhang, Donglei, Glotzer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552957/
https://www.ncbi.nlm.nih.gov/pubmed/26252513
http://dx.doi.org/10.7554/eLife.08898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552957/
https://www.ncbi.nlm.nih.gov/pubmed/26252513
http://dx.doi.org/10.7554/eLife.08898

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