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RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation

The retinoic acid (RA)- and β-catenin-signaling pathways regulate limb bud induction and initiation; however, their mechanisms of action are not understood and have been disputed. We demonstrate that both pathways are essential and that RA and β-catenin/TCF/LEF signaling act cooperatively with Hox g...

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Detalles Bibliográficos
Autores principales: Nishimoto, Satoko, Wilde, Susan M., Wood, Sophie, Logan, Malcolm P.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553633/
https://www.ncbi.nlm.nih.gov/pubmed/26212321
http://dx.doi.org/10.1016/j.celrep.2015.06.068