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Growth Retardation, General Hypotonia, and Loss of Acquired Neuromotor Skills in the Infants of Mothers With Cobalamin Deficiency and the Possible Role of Succinyl-CoA and Glycine in the Pathogenesis
Vitamin B(12) (cobalamin, Cbl) deficiency can cause metabolic, hematological, and neurological abnormalities. Adequate levels of succinyl-coenzyme A (CoA) cannot be synthesized from methylmalonyl-CoA because of the decreased activity of the methylmalonyl-CoA mutase enzyme that uses Cbl as the cofact...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Wolters Kluwer Health
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553967/ https://www.ncbi.nlm.nih.gov/pubmed/25738478 http://dx.doi.org/10.1097/MD.0000000000000584 |