Modification of paclitaxel-loaded solid lipid nanoparticles with 2-hydroxypropyl-β-cyclodextrin enhances absorption and reduces nephrotoxicity associated with intravenous injection

BACKGROUND: Paclitaxel (PTX) solid lipid nanoparticles (SLNs) modified with 2-hydroxypropyl-β-cyclodextrin (HPCD) were evaluated for their ability to enhance PTX absorption and reduce the nephrotoxicity accompanying intravenous administration. METHODS: PTX-loaded SLNs (PS) and PTX-loaded SLNs modifi...

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Detalles Bibliográficos
Autores principales: Baek, Jong-Suep, Kim, Ju-Heon, Park, Jeong-Sook, Cho, Cheong-Weon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554395/
https://www.ncbi.nlm.nih.gov/pubmed/26347363
http://dx.doi.org/10.2147/IJN.S86474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554395/
https://www.ncbi.nlm.nih.gov/pubmed/26347363
http://dx.doi.org/10.2147/IJN.S86474

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