Spray-dried powders enhance vaginal siRNA delivery by potentially modulating the mucus molecular sieve structure

Vaginal small interfering RNA (siRNA) delivery provides a promising strategy for the prevention and treatment of vaginal diseases. However, the densely cross-linked mucus layer on the vaginal wall severely restricts nanoparticle-mediated siRNA delivery to the vaginal epithelium. In order to overcome...

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Detalles Bibliográficos
Autores principales: Wu, Na, Zhang, Xinxin, Li, Feifei, Zhang, Tao, Gan, Yong, Li, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554414/
https://www.ncbi.nlm.nih.gov/pubmed/26347257
http://dx.doi.org/10.2147/IJN.S87978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554414/
https://www.ncbi.nlm.nih.gov/pubmed/26347257
http://dx.doi.org/10.2147/IJN.S87978

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