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Spray-dried powders enhance vaginal siRNA delivery by potentially modulating the mucus molecular sieve structure

Vaginal small interfering RNA (siRNA) delivery provides a promising strategy for the prevention and treatment of vaginal diseases. However, the densely cross-linked mucus layer on the vaginal wall severely restricts nanoparticle-mediated siRNA delivery to the vaginal epithelium. In order to overcome...

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Detalles Bibliográficos
Autores principales:	Wu, Na, Zhang, Xinxin, Li, Feifei, Zhang, Tao, Gan, Yong, Li, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554414/ https://www.ncbi.nlm.nih.gov/pubmed/26347257 http://dx.doi.org/10.2147/IJN.S87978

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