New developments in atherosclerosis: clinical potential of PCSK9 inhibition

Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is a secreted 692-amino acid protein that binds surface low-density lipoprotein (LDL) receptor (LDLR) and targets it toward lysosomal degradation. As a consequence, the number of LDLRs at the cell surface is decreased, and LDL-cholesterol (LDL-C...

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Detalles Bibliográficos
Autores principales: Giunzioni, Ilaria, Tavori, Hagai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554462/
https://www.ncbi.nlm.nih.gov/pubmed/26345307
http://dx.doi.org/10.2147/VHRM.S74692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554462/
https://www.ncbi.nlm.nih.gov/pubmed/26345307
http://dx.doi.org/10.2147/VHRM.S74692

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