Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors

The botulinum neurotoxin type D is one of seven highly potent toxins produced by Clostridium botulinum which inhibit neurotransmission at cholinergic nerve terminals. A functional fragment derived from the toxin, LHn, consisting of the catalytic and translocation domains, has been heralded as a plat...

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Detalles Bibliográficos
Autores principales: Masuyer, Geoffrey, Davies, Jonathan R., Moore, Kevin, Chaddock, John A., Ravi Acharya, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555039/
https://www.ncbi.nlm.nih.gov/pubmed/26324071
http://dx.doi.org/10.1038/srep13397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555039/
https://www.ncbi.nlm.nih.gov/pubmed/26324071
http://dx.doi.org/10.1038/srep13397

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