Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli

The limited supply of intracellular malonyl-CoA in Escherichia coli impedes the biological synthesis of polyketides, flavonoids and biofuels. Here, a clustered regularly interspaced short palindromic repeats (CRISPR) interference system was constructed for fine-tuning central metabolic pathways to e...

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Detalles Bibliográficos
Autores principales: Wu, Junjun, Du, Guocheng, Chen, Jian, Zhou, Jingwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555050/
https://www.ncbi.nlm.nih.gov/pubmed/26323217
http://dx.doi.org/10.1038/srep13477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555050/
https://www.ncbi.nlm.nih.gov/pubmed/26323217
http://dx.doi.org/10.1038/srep13477

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