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PrP charge structure encodes interdomain interactions

Almost all proteins contain charged residues, and their chain distribution is tailored to fulfill essential ionic interactions for folding, binding and catalysis. Among proteins, the hinged two-domain chain of the cellular prion protein (PrP(C)) exhibits a peculiar charge structure with unclear cons...

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Detalles Bibliográficos
Autores principales: Martínez, Javier, Sánchez, Rosa, Castellanos, Milagros, Makarava, Natallia, Aguzzi, Adriano, Baskakov, Ilia V., Gasset, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555102/
https://www.ncbi.nlm.nih.gov/pubmed/26323476
http://dx.doi.org/10.1038/srep13623