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Whole Organism Genome Editing: Targeted Large DNA Insertion via ObLiGaRe Nonhomologous End-Joining in Vivo Capture

Targeted gene insertion is a goal of genome editing and has been performed in cultured cells but only in a handful of whole organisms. The existing method to integrate foreign DNA using the homologous recombination pathway is inherently low efficiency, and many systems are refractory to this method....

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Detalles Bibliográficos
Autores principales: Yamamoto, Yutaka, Bliss, Jacob, Gerbi, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555220/
https://www.ncbi.nlm.nih.gov/pubmed/26139843
http://dx.doi.org/10.1534/g3.115.019901