The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

B lymphocytes use B cell receptors (BCRs) to sense the physical features of the antigens. However, the sensitivity and threshold for the activation of BCRs resulting from the stimulation by mechanical forces are unknown. Here, we addressed this question using a double-stranded DNA-based tension gaug...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Zhengpeng, Chen, Xiangjun, Chen, Haodong, Ji, Qinghua, Chen, Yingjia, Wang, Jing, Cao, Yiyun, Wang, Fei, Lou, Jizhong, Tang, Zhuo, Liu, Wanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555871/
https://www.ncbi.nlm.nih.gov/pubmed/26258882
http://dx.doi.org/10.7554/eLife.06925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555871/
https://www.ncbi.nlm.nih.gov/pubmed/26258882
http://dx.doi.org/10.7554/eLife.06925

Ejemplares similares