IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. Here we show that IL-21 unexpectedly induces IL-1β production in conventional dendritic cells (cDCs) via a STAT3-depende...

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Detalles Bibliográficos
Autores principales: Wan, Chi-Keung, Li, Peng, Spolski, Rosanne, Oh, Jangsuk, Andraski, Allison B., Du, Ning, Yu, Zu-Xi, Dillon, Christopher P., Green, Douglas R., Leonard, Warren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555999/
https://www.ncbi.nlm.nih.gov/pubmed/26269257
http://dx.doi.org/10.1038/ncomms8988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555999/
https://www.ncbi.nlm.nih.gov/pubmed/26269257
http://dx.doi.org/10.1038/ncomms8988

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