Cargando…

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. Here we show that IL-21 unexpectedly induces IL-1β production in conventional dendritic cells (cDCs) via a STAT3-depende...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wan, Chi-Keung, Li, Peng, Spolski, Rosanne, Oh, Jangsuk, Andraski, Allison B., Du, Ning, Yu, Zu-Xi, Dillon, Christopher P., Green, Douglas R., Leonard, Warren J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555999/ https://www.ncbi.nlm.nih.gov/pubmed/26269257 http://dx.doi.org/10.1038/ncomms8988

Ejemplares similares

The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
por: Spolski, Rosanne, et al.
Publicado: (2017)

IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus
por: Spolski, Rosanne, et al.
Publicado: (2019)

Synergy of IL-21 and IL-15 in regulating CD8(+) T cell expansion and function
por: Zeng, Rong, et al.
Publicado: (2005)

IL-21 Signaling in Immunity
por: Leonard, Warren J., et al.
Publicado: (2016)

Regulatory B Cells Control T Cell Autoimmunity Through IL-21-Dependent Cognate Interactions
por: Yoshizaki, Ayumi, et al.
Publicado: (2012)

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity
por: Cho, Hyeseon, et al.
Publicado: (2018)

Thymic stromal lymphopoietin limits primary and recall CD8(+) T-cell anti-viral responses
por: Ebina-Shibuya, Risa, et al.
Publicado: (2021)

Priming for T helper type 2 differentiation by interleukin 2-mediated induction of IL-4 receptor α chain expression
por: Liao, Wei, et al.
Publicado: (2008)

Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice
por: Sakuraba, Koji, et al.
Publicado: (2016)

Differential Capacity of Human Skin Dendritic Cells to Polarize CD4(+)T Cells into IL-17, IL-21 and IL-22 Producing Cells
por: Penel-Sotirakis, Karine, et al.
Publicado: (2012)

MicroRNA-30b Is Both Necessary and Sufficient for Interleukin-21 Receptor-Mediated Angiogenesis in Experimental Peripheral Arterial Disease
por: Wang, Tao, et al.
Publicado: (2021)

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4(+) T cells
por: Dienz, Oliver, et al.
Publicado: (2009)

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
por: Lin, Jian-Xin, et al.
Publicado: (2017)

A role for TSLP in the development of inflammation in an asthma model
por: Al-Shami, Amin, et al.
Publicado: (2005)

IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
por: Tzartos, John S., et al.
Publicado: (2011)

Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
por: Yao, Yongxue, et al.
Publicado: (2005)

IL-2, IL-15 and IL-21 expand T cells for targeted adoptive therapy
por: Liu, Zhenjiang, et al.
Publicado: (2015)

IL-21 and Sjögren's syndrome
por: Scofield, R Hal
Publicado: (2011)

Comprehensive assembly of novel transcripts from unmapped human RNA-Seq data and their association with cancer
por: Kazemian, Majid, et al.
Publicado: (2015)

Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU)
por: Liu, Lan, et al.
Publicado: (2009)

IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling
por: Floss, D. M., et al.
Publicado: (2017)

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
por: Petrelli, Alessandra, et al.
Publicado: (2011)

The Role of IL-23, IL-22, and IL-18 in Campylobacter Jejuni Infection of Conventional Infant Mice
por: Heimesaat, Markus M., et al.
Publicado: (2016)

Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
por: Ma, Xiaojing, et al.
Publicado: (2015)

IL-21 induces IL-22 production in CD4+ T-cells
por: Yeste, Ada, et al.
Publicado: (2014)

IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and High Levels of IL-21 Are Associated with Rheumatoid Arthritis in Mexican Patients
por: Carreño-Saavedra, Noemi Magdalena, et al.
Publicado: (2023)

IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients
por: de Oliveira, Priscilla Stela Santana, et al.
Publicado: (2015)

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
por: Schmitz, Iwana, et al.
Publicado: (2013)

Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome
por: Ainscough, Joseph S., et al.
Publicado: (2014)

Role of IL-37- and IL-37-Treated Dendritic Cells in Acute Coronary Syndrome
por: Zhu, Ruirui, et al.
Publicado: (2021)

Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation
por: Gualdoni, Guido A., et al.
Publicado: (2015)

The Roles of IL-17, IL-21, and IL-23 in the Helicobacter pylori Infection and Gastrointestinal Inflammation: A Review
por: Dewayani, Astri, et al.
Publicado: (2021)

IL-10 control of dendritic cells in the skin
por: Clausen, Björn E., et al.
Publicado: (2013)

STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
por: Santarelli, Roberta, et al.
Publicado: (2014)

Serum levels of IL-12, IL-18, and IL-21 are indicators of viral load in patients chronically infected with HBV
por: Zhou, Fangye, et al.
Publicado: (2022)

BATF-JUN is critical for IRF4-mediated transcription in T cells
por: Li, Peng, et al.
Publicado: (2012)

IL-21/IL-21R Regulates the Neutrophil-Mediated Pathologic Immune Response during Chlamydial Respiratory Infection
por: Zeng, Jiajia, et al.
Publicado: (2022)

IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection
por: Yang, Shuaini, et al.
Publicado: (2023)

P16-30. Induction of Tim-3 expression by the common gamma-chain cytokines IL-2, IL-7, IL-15 and IL-21
por: Jones, BR, et al.
Publicado: (2009)

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders—The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3
por: Gałecka, Małgorzata, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pd49shh85nkndjsns3bot5mj67