Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies

BACKGROUND: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenoty...

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Detalles Bibliográficos
Autores principales: Ruzycki, Philip A., Tran, Nicholas M., Kefalov, Vladimir J., Kolesnikov, Alexander V., Chen, Shiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556057/
https://www.ncbi.nlm.nih.gov/pubmed/26324254
http://dx.doi.org/10.1186/s13059-015-0732-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556057/
https://www.ncbi.nlm.nih.gov/pubmed/26324254
http://dx.doi.org/10.1186/s13059-015-0732-z

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