Cargando…
Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies
BACKGROUND: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenoty...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556057/ https://www.ncbi.nlm.nih.gov/pubmed/26324254 http://dx.doi.org/10.1186/s13059-015-0732-z |