Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

BRCA1 and 53BP1 antagonistically regulate homology-directed repair (HDR) and non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSB). The histone deacetylase (HDAC) inhibitor trichostatin A directly inhibits the retention of 53BP1 at DSB sites by acetylating histone H4 (H4ac), which inte...

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Detalles Bibliográficos
Autores principales: Fukuda, Takayo, Wu, Wenwen, Okada, Maiko, Maeda, Ichiro, Kojima, Yasuyuki, Hayami, Ryosuke, Miyoshi, Yasuo, Tsugawa, Ko-ichiro, Ohta, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556395/
https://www.ncbi.nlm.nih.gov/pubmed/26053117
http://dx.doi.org/10.1111/cas.12717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556395/
https://www.ncbi.nlm.nih.gov/pubmed/26053117
http://dx.doi.org/10.1111/cas.12717

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