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Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

BRCA1 and 53BP1 antagonistically regulate homology-directed repair (HDR) and non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSB). The histone deacetylase (HDAC) inhibitor trichostatin A directly inhibits the retention of 53BP1 at DSB sites by acetylating histone H4 (H4ac), which inte...

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Detalles Bibliográficos
Autores principales:	Fukuda, Takayo, Wu, Wenwen, Okada, Maiko, Maeda, Ichiro, Kojima, Yasuyuki, Hayami, Ryosuke, Miyoshi, Yasuo, Tsugawa, Ko-ichiro, Ohta, Tomohiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556395/ https://www.ncbi.nlm.nih.gov/pubmed/26053117 http://dx.doi.org/10.1111/cas.12717

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