Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity

BACKGROUND AND PURPOSE: Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB(1/2)). Because the CB(1) receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion...

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Detalles Bibliográficos
Autores principales: Taschler, U, Eichmann, T O, Radner, F P W, Grabner, G F, Wolinski, H, Storr, M, Lass, A, Schicho, R, Zimmermann, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556478/
https://www.ncbi.nlm.nih.gov/pubmed/26075589
http://dx.doi.org/10.1111/bph.13224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556478/
https://www.ncbi.nlm.nih.gov/pubmed/26075589
http://dx.doi.org/10.1111/bph.13224

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