Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes

BACKGROUND: Breast cancer patients who are resistant to neoadjuvant chemotherapy (NeoCT) have a poor prognosis. There is a pressing need to develop in vivo models of chemo resistant tumors to test novel therapeutics. We hypothesized that patient-derived breast cancer xenografts (BCXs) from chemo- na...

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Detalles Bibliográficos
Autores principales: McAuliffe, Priscilla F., Evans, Kurt W., Akcakanat, Argun, Chen, Ken, Zheng, Xiaofeng, Zhao, Hao, Eterovic, Agda Karina, Sangai, Takafumi, Holder, Ashley M., Sharma, Chandeshwar, Chen, Huiqin, Do, Kim-Anh, Tarco, Emily, Gagea, Mihai, Naff, Katherine A., Sahin, Aysegul, Multani, Asha S., Black, Dalliah M., Mittendorf, Elizabeth A., Bedrosian, Isabelle, Mills, Gordon B., Gonzalez-Angulo, Ana Maria, Meric-Bernstam, Funda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556673/
https://www.ncbi.nlm.nih.gov/pubmed/26325287
http://dx.doi.org/10.1371/journal.pone.0136851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556673/
https://www.ncbi.nlm.nih.gov/pubmed/26325287
http://dx.doi.org/10.1371/journal.pone.0136851

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