SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway

The mammalian target of rapamycin (mTOR) is extensively involved in multiple myeloma (MM) pathophysiology. In the present study, we reported a novel small molecule SC06 that induced MM cell apoptosis and delayed MM xenograft growth in vivo. Oral administration of SC06 to mice bearing human MM xenogr...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Kunkun, Xu, Xin, Xu, Zhuan, Chen, Guodong, Zeng, Yuanying, Zhang, Zubin, Cao, Biyin, Kong, Yan, Tang, Xiaowen, Mao, Xinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556980/
https://www.ncbi.nlm.nih.gov/pubmed/26329846
http://dx.doi.org/10.1038/srep12809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556980/
https://www.ncbi.nlm.nih.gov/pubmed/26329846
http://dx.doi.org/10.1038/srep12809

Ejemplares similares