Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

BACKGROUND & AIMS: Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium release–activated calcium modulator ORAI1 is the most abundant Ca(2+) entry channel in pancreatic acinar cells; it sustains calcium overload in mice...

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Detalles Bibliográficos
Autores principales: Wen, Li, Voronina, Svetlana, Javed, Muhammad A., Awais, Muhammad, Szatmary, Peter, Latawiec, Diane, Chvanov, Michael, Collier, David, Huang, Wei, Barrett, John, Begg, Malcolm, Stauderman, Ken, Roos, Jack, Grigoryev, Sergey, Ramos, Stephanie, Rogers, Evan, Whitten, Jeff, Velicelebi, Gonul, Dunn, Michael, Tepikin, Alexei V., Criddle, David N., Sutton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556985/
https://www.ncbi.nlm.nih.gov/pubmed/25917787
http://dx.doi.org/10.1053/j.gastro.2015.04.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556985/
https://www.ncbi.nlm.nih.gov/pubmed/25917787
http://dx.doi.org/10.1053/j.gastro.2015.04.015

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