High-Level Expression, Purification and Large-Scale Production of l-Methionine γ-Lyase from Idiomarina as a Novel Anti-Leukemic Drug

l-Methionine γ-lyase (MGL), a pyridoxal 5′-phosphate-dependent enzyme, possesses anti-tumor activity. However, the low activity of MGL blocks the anti-tumor effect. This study describes an efficient production process for the recombinant MGL (rMGL) from Idiomarina constructed using the overexpressio...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Kui-Ying, Hu, Hai-Yan, Tang, Yan-Lai, Xia, Feng-Geng, Luo, Xue-Qun, Liu, Jian-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557031/
https://www.ncbi.nlm.nih.gov/pubmed/26308011
http://dx.doi.org/10.3390/md13085492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557031/
https://www.ncbi.nlm.nih.gov/pubmed/26308011
http://dx.doi.org/10.3390/md13085492

Ejemplares similares