Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells

Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8(+) T cells requires cortical thymic epithelial cells th...

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Detalles Bibliográficos
Autores principales: Sasaki, Katsuhiro, Takada, Kensuke, Ohte, Yuki, Kondo, Hiroyuki, Sorimachi, Hiroyuki, Tanaka, Keiji, Takahama, Yousuke, Murata, Shigeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557289/
https://www.ncbi.nlm.nih.gov/pubmed/26099460
http://dx.doi.org/10.1038/ncomms8484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557289/
https://www.ncbi.nlm.nih.gov/pubmed/26099460
http://dx.doi.org/10.1038/ncomms8484

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